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Survival impact of survivin expression, p53 accumulation, and Ki67 index in endometrial carcinoma.
Patients with endometrial carcinoma with a high expression of survivin were demonstrated to have a better prognosis than those with low expression. However, its correlation with clinicopathological factors is unknown. In this study, survivin, p53 accumulation, and Ki67 index were analyzed in 102 endometrial carcinomas. The Ki67 index was significantly lower in survivin positive cases than in survivin negative cases (P = 0.039). However, p53 accumulation and tumor grade and stage were not correlated with survivin expression. Among the clinicopathological factors, the Ki67 index was significantly lower in FIGO stage III than in FIGO stage I-II (P = 0.015). When the Ki67 index was categorized into 2 groups, the patient survival rate was significantly higher in low Ki67 index cases than in high Ki67 index cases (P = 0.018). Survivin was negatively correlated with p53 accumulation (P = 0.022) and Ki67 index (P = 0.037). Survivin was positively correlated with disease free survival and overall survival (P Isolation of a major antigen common to hepatitis C virus (HCV) and hepatitis B virus (HBV) and the characterization of the amino acids that are essential for its biological activity.
A new substance, which has been isolated from both hepatitis B and C virus-infected sera, was characterized as a glycoprotein of the hepatitis B virus (HBV) surface antigen. The substance was found to exist in both free and complexed forms in the serum. In the human anti-HBV-positive serum the glycoprotein was detected in about 50 ng/ml by the sandwich ELISA method. When the two-dimensional electrophoretic profile of the glycop be359ba680
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